- OH! NO!
- OH GOD... (Episode Two)
- OH GOD THAT STATUE'S ALIVE
- OH IT'S A
- OH YEAH
- ONE DAY for Ched
- OOHHH NOOOOOO
- Obabacare
- Obama's Back, Baby
- Obama Watches Game Grumps
- Obama Watches Game Grumps (Game Grumps Animated)
- Ocean Side
- Octogeddon
- Octogeddon (episode)
- Octopimp
- Odd1sout Masters BASIC Phonics
- Odd Jobs
- Odd Photographer
- Odd Zombies
- Oddworld: Abe’s Oddysee
- Ode to Jon
- Odorless Baby Poop
- Off the Hook
- Off the Hook (Silent Hill 4: The Room)
- Off the Rails
- Off the Rails (Undertale)
- Off the Top
- Off to Death!
- Off to Summer Camp
- Offspring Fling!
- Oh! It's a Gamsmash
- Oh, Grandma
- Oh, Sweet Deku Tree
- Oh, Tails
- Oh, Thanks Bottles
- Oh, that was stronger than we thought...
- Oh... Koops...
- Oh Boy Oh Girl
- Oh Dear
- Oh Deer
- Oh Deer!
- Oh FATHER
- Oh Goodness Me!
- Oh Hey, an Abomination
- Oh Maya God
- Oh My Badness
- Oh My God It's Happening...
- Oh No
- Oh No! It's Wesker
- Oh No for Two Reasons
- Oh Oh Oh
- Oh That Ganon!
- Oh god (Episode One)
- Oh no, everyone's COUNTING ON ME!
- Oh no, this voice acting...
- Oh the Brutality
- Oh the calamity!
- Ohmygodohmygod
- Ok Sonic... DO YOUR WORST
- Okay, This Is Easy... Whoops
- Ol' Ladies Blockin' the Road
- Old 45's
- Old Bitty
- Old Don Pianta
- Old Dragonslayer
- Old Foes
- Old Man Exposition
- Old Man Goomba
- Old School RuneScape
- Old Toons
- Old Town Road
- Old Wonky
- Oldbag and Boujee
- OlliOlli
- OlliOlli (episode)
- Olympic Bone Zone
- On Edge
- On Fire
- On Par
- On The Fence
- On a Roll
- On a Roll (Donkey Kong Country 2: Diddy's Kong Quest)
- On a Roll (Donkey Kong Country 3: Dixie Kong's Double Trouble!)
- On a Roll (Katamari Forever)
- On a Wire
- On the Horn
- On the Hunt!
- On the Level
- Once Upon a Coma
- Once Upon a Coma (episode)
- One-Armed Cook
- One Angry Mother
- One Bonus Child
- One Bread Ahead of the Bread
- One Buff Boss
- One Buggy Game
- One Eyed Monster
- One Hard Waluigi
- One Last Chance
- One Last Hope
- One Last Try To This Situation
- One Manga Day: A Day in the Life of Manga Translators
- One More Go!
- One More Shot
- One Night Ultimate Werewolf
- One Piece Mansion
- One Scary Dude
- One Sided
- One Sledgehammer and a Little Determination
- One Strike
- One Strike (episode)
- One Ups the Wazoo
- One Versus Three
- One With The Mu
- One and Done (Donkey Kong Country: Tropical Freeze)
- One and Done (Kirby's Dream Course)
- One final rocket punch
- One for the Road
- One of Those Days
- One of us is an OTHELLO MASTER
- Onechanbara Z2: Chaos
- Oney
- Oniken
- Only 10 Coins
- Only If
- Only If (episode)
- Onward Ho!
- Oodles of Noodles
- Ooh La La
- Oops Jiggle Wink
- Oops haha
- Open Sesame
- Open The Gates!
- Open the Grave
- Opening Doors
- Operation Choperation
- Operation Clone Burger
- Operation Cool
- Opinions and Facts and Opinions
- Opposite Day
- Oprah Winfrey Fan Club
- Options
- Orange and Blue
- OrbusVR
- OrbusVR (episode)
- Order Up!
- Organ Trail
- Orph
- Ostrich Island
- Ostrich Island (episode)
- Other Sonic
- Otto
- Our EMOTIONALLY STABLE RETURN to A Link Between Worlds!
- Our House
- Our KFC Conspiracy Theory - Tier List: Fast Food
- Our Robot Child!
- Our Son is Weak
- Our Uncle Sucks
- Our best Far Cry 6 DLC episode ever
- Our dream job sucks.
- Our friend is in this game! (Also Dan screams)
- Our most important video ever - Tier List: Hottest Mascots
- Out On The Town
- Out for Blood
- Out of Batteries
- Out of Control (Bloodborne episode)
- Out of Control (Kirby and the Rainbow Curse episode)
- Out of Sight!
- Out of This World
- Out of the Way!
- Out the Window
- Outlast
- Outlaw Golf: 9 Holes of X-Mas
- Outstanding Reviews
- Ouya
- Oven-roasted friendship for the WIN!!!
- Over The Edge
- Over Whaleming
- Over and Over
- Over or Under
- Over the Edge
- Overcomplicating
- Overcooked 2
- Overgrown Mushroom Cloudtops: NOT WHAT YOU THINK!
- Overpowered
- Overtime
- Overwatch
- Overwatch (The G Club)
- Overwhelming Odds
- Ow Ow Laser Sword
- Owen Wowson
- Owie!
- Owl Boy
- Owning Mistakes
- Oxenfree
- Oxenfree (episode)
- P-P-PANTIES?!??!?!
- P.T.
- P.T. (episode)
- PACKED with Peanuts
- PARTYING like it's 1999
- PARTY UP IN HERE
- PA Guy
- PEEHAT
- PEPSIMAN (episode)
- PICO PARK
- POISONED
- POP goes the Nagito
- POUNDING some huge muscly dudes!!
- PP Gaming
- PRETTY GOOD
- PROTECT THE PRECIOUS!
- PUBG MOBILE
- PUNCH HIM
- Pac-Attack
- Pac-Attack (episode)
- Pac-In-Time
- Pac-In-Time (episode)
- Pac-Man Championship Edition 2 PLUS
- Pac-Man Fever
- Pachinko Party
- Pachinko Town
- Pacific Rim: Behind the Scenes
- Pacific Rim Video Now on Polaris!
- Pacify
- Pain
- Pain (episode)
- Pain in the Neck
- Paint By Numbers
- Pair-a-Site
- Paleoproterozoic Perils
- Palette Swap'd
- Pancakes
- Pancakes of Love
- Panel Attack
- Panic Attack
- Panic Mode
- Panic Restaurant
- Panoptic
- Pants Quest
- Pantsu Hunter: Back to the 90s
- Panty Party
- Paparazzi Panic
- Paper Mario: The Thousand-Year Door
- Paper Thin Pals
- Paperboy
- Paperboy 64
- Paperboy 64 (episode)
- Papers, Please
- Papers, Please (episode)
- Par Tee
- Para Eyes
- ParanoiaScape
- Paranormaling
- Paratopic
- Parodius! From Myth to Laughter
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